Bravo with AET cut-off >4.2% captured an additional 59.1% of cases with increased AET ( p 4.4% and >5.3%. Our study group (male = 14 and female = 30) successfully completed Bravo studies beyond 48 hours in 97.7%. Statistical analysis was performed using SPSS v20. Subgroups (B) and (C) have normal number of acid reflux events.

Subgroup analyses were subsequently made on cohorts whose MII-pH showed normal AET with (A) normal number of total reflux episodes, (B) normal number of non-acid reflux (NAR) events and (C) increased number of NAR events. Reference values for MII-pH and Bravo equivalent were adopted from internationally established studies. Cases with an abnormal acid exposure time (AET) were used as primary end-point based on ‘worst day analysis’. Bravo studies were performed off PPI over an extended period beyond 48 hrs (up to 96 hrs). A total of 44 patients with GORD symptoms but normal MII-pH studies off proton pump inhibitor (PPI) were referred for Bravo capsule studies. This study aims to assess the additional diagnostic yield of extended Bravo recordings (up to 96 hours) in patients with normal 24 hr MII-pH results. Wireless pH capsule (Bravo) can potentially increase the diagnostic yield of standard 24 hr catheter-based studies with prolonged monitoring.

Extended Bravo studies (>48 hrs) offer an additional diagnostic yield of gastro-oesophageal reflux disease (GORD) in patients with normal multichannel intraluminal impedance-pH (MII-pH) studiesĬhristopher Tze Wei Chia 1, Ismail Miah 2, Jafar Jafari 2, Ikram Nasr 2, Ioannis Koumoutsos 2 and Terence Wong 2ġ Gastroenterology, Tan Tock Seng Hospital, Singapore 2 Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, UK

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